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apalutamide will lessen the level or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine which have been CYP3A4 substrates may result in reduce publicity to those medications.As such, these probable potential app